KMID : 0858420120140010019
|
|
Korean Journal of Stroke 2012 Volume.14 No. 1 p.19 ~ p.28
|
|
Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients
|
|
Kim Wook-Joo
Kwon O-Ki Oh Chang-Wan Jung Cheol-Kyu Lee Ji-Sung Lee June-Young Park Jung-Hyun Ko Young-Chai Jang Myung-Suk Yang Mi-Hwa Han Moon-Ku Bae Hee-Joon
|
|
Abstract
|
|
|
Thrombolysis becomes an emerging therapeutic option for acute ischemic stroke. However, few reports exist on its use in the very elderly. We investigated whether there is a difference in the effectiveness and safety of intravenous (IV) and/ or intra-arterial (IA) thrombolysis between patients aged ¡Ã80 years and those aged <80 years. Methods: A consecutive series of patients hospitalized within 12 hours from stroke onset were selected. We evaluated the effectiveness of thrombolysis with modified Rankin scale (mRS) at 3 months, and the safety with symptomatic hemorrhagic transformation (sHT). The odds ratio (OR) of thrombolysis on the favorable mRS (0-2) was calculated using multivariable logistic regression analysis with adjustments for potential confounders. Whether the effectiveness of thrombolysis is age-dependent or not was analyzed by introducing an interaction term (thrombolysis¡¿age group) into multivariable models. Results: Among 219 patients ¡Ã80 years, 21% of patients received IV or IA or combined thrombolysis while 23% of 980 patients <80 years received thrombolysis (P =0.51). With respect to the favorable mRS, the adjusted ORs of thrombolysis were 1.70 (95% confi dence interval, 1.08-2.68) in all subjects, 1.61 (0.58-4.49) in those ¡Ã80 years, and 1.71 (1.05-2.78) in those <80 years. There was no signifi cant interaction between age group and thrombolysis (P =0.91). With respect to sHT, the adjusted OR was 4.72 (1.94-11.45) in all subjects with no signifi cant interaction (P =0.86). Conclusion: This study suggests that thrombolysis may be equally safe and effective in stroke patients aged ¡Ã80 years versus <80 years. (Korean J Stroke 2012;14:19-28)
|
|
KEYWORD
|
|
Thrombolysis, Treatment outcome, Aged 80 and over
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|